Combination of Glucosamine and Chondroitin for joint nutrition and cartilage protection. What is Glucosamine Hydrochloride 500mg with Chondroitin Sulphate 400mg? Glucosamine is an amino sugar that the body produces and distributes in cartilage and other connective tissue for building the cartilage1. Chondroitin sulphate is a complex carbohydrate that helps cartilage retain water1. How does Glucosamine Hydrochloride 500mg with Chondroitin Sulphate 400mg help in maintaining joint health? Glucosamine functions to normalize cartilage metabolism and helps to repair damaged cartilage2. It stimulates the production of glycosaminoglycans (GAGs), proteoglycans and collagen in the joint cartilage matrix and synovial fluid, all of which are important to prevent the breakdown of cartilage3. Chondroitin acts like water magnet to absorb water into connective tissue and provides shock absorption3. It may also block enzymes that break down cartilage, and it provides the building blocks for the body to produce new cartilage3. Who are recommended to take Glucosamine Hydrochloride 500mg with Chondroitin Sulphate 400mg? People with moderate to severe osteoarthritis. What is the recommended dosage? Light to moderate: 1 tablet twice daily, 15 minutes before meals for at least 6 weeks (or according to medical prescription) Severe osteoarthritis symptoms: Initial therapy: 1 tablet 3 times daily, 15 minutes before meals during a period of at least 8 weeks. Follow-up therapy: 1 tablet twice daily, 15 minutes before meals during a period of at least 8 weeks. What are the features of Glucosamine Hydrochloride 500mg with Chondroitin Sulphate 400mg? Formulated based on the dosage used in Glucosamine/ Chondroitin Arthritis Intervention Trial (GAIT) in 2008.